Cortical excitability is abnormal in patients with the “fixed dystonia” syndrome
Identifieur interne : 002921 ( Main/Exploration ); précédent : 002920; suivant : 002922Cortical excitability is abnormal in patients with the “fixed dystonia” syndrome
Auteurs : Laura Avanzino [Royaume-Uni, Italie] ; Davide Martino [Royaume-Uni, Italie] ; Bart P. C. Van De Warrenburg [Royaume-Uni, Pays-Bas] ; Susanne A. Schneider [Royaume-Uni] ; Giovanni Abbruzzese [Italie] ; Giovanni Defazio [Italie] ; Anette Schrag [Royaume-Uni] ; Kailash P. Bhatia [Royaume-Uni] ; John C. Rothwell [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-04-15.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Adult, Cerebral Cortex (physiopathology), Dystonia, Dystonic Disorders (classification), Dystonic Disorders (diagnosis), Dystonic Disorders (physiopathology), Electrodiagnosis, Evoked Potentials, Motor, Excitability, Female, Functional Laterality, Human, Humans, Male, Middle Aged, Motor cortex, Nervous system diseases, Neural Inhibition, Reaction Time, Syndrome, TMS, Transcranial Magnetic Stimulation, dystonia, motor cortex.
- MESH :
- classification : Dystonic Disorders.
- diagnosis : Dystonic Disorders.
- physiopathology : Cerebral Cortex, Dystonic Disorders.
- Adult, Electrodiagnosis, Evoked Potentials, Motor, Female, Functional Laterality, Humans, Male, Middle Aged, Neural Inhibition, Reaction Time, Syndrome, Transcranial Magnetic Stimulation.
Abstract
A form of fixed dystonia (FD) without evidence of basal ganglia lesions or neurodegeneration has been recently characterized (Schrag et al., Brain 2004;127:2360‐2372), which may overlap the clinical spectrum of either complex regional pain syndrome or psychogenic dystonia. Transcranial magnetic stimulation studies in typically mobile dystonia revealed abnormal motor cortical excitability and sensori‐motor integration. We compared 12 patients with limb FD to 10 patients with primary adult‐onset typically mobile dystonia and 11 age‐matched healthy volunteers. Measurements at the first digital interosseus representation area on both hemispheres included: short intracortical inhibition (SICI), contralateral silent period (cSP), and short and long afferent inhibition (SAI and LAI). Repeated measure ANOVA and post‐hoc t‐tests were used for statistical analysis. SICI was significantly reduced in both hemispheres of patients with “typical” and FD, compared to healthy subjects. For both hemispheres, cSP duration was shorter in both fixed and “typical” dystonia patients. SAI and LAI did not significantly differ between the three groups. The abnormal cortical excitability observed in FD might represent an underlying trait predisposing to different clinical forms of dystonia. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21801
Affiliations:
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C." last="Van De Warrenburg">Bart P. C. Van De Warrenburg</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience, Institute of Neurology, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Radboud University Nijmegen Medical Centre, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Schneider, Susanne A" sort="Schneider, Susanne A" uniqKey="Schneider S" first="Susanne A." last="Schneider">Susanne A. 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Bhatia</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience, Institute of Neurology, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Rothwell, John C" sort="Rothwell, John C" uniqKey="Rothwell J" first="John C." last="Rothwell">John C. Rothwell</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience, Institute of Neurology, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-04-15">2008-04-15</date><biblScope unit="vol">23</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="646">646</biblScope><biblScope unit="page" to="652">652</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">9B2034ED1C3E405CC208BA8D71FE627587770026</idno><idno type="DOI">10.1002/mds.21801</idno><idno type="ArticleID">MDS21801</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Cerebral Cortex (physiopathology)</term><term>Dystonia</term><term>Dystonic Disorders (classification)</term><term>Dystonic Disorders (diagnosis)</term><term>Dystonic Disorders (physiopathology)</term><term>Electrodiagnosis</term><term>Evoked Potentials, Motor</term><term>Excitability</term><term>Female</term><term>Functional Laterality</term><term>Human</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Motor cortex</term><term>Nervous system diseases</term><term>Neural Inhibition</term><term>Reaction Time</term><term>Syndrome</term><term>TMS</term><term>Transcranial Magnetic Stimulation</term><term>dystonia</term><term>motor cortex</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Dystonic Disorders</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Dystonic Disorders</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Cerebral Cortex</term><term>Dystonic Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Electrodiagnosis</term><term>Evoked Potentials, Motor</term><term>Female</term><term>Functional Laterality</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neural Inhibition</term><term>Reaction Time</term><term>Syndrome</term><term>Transcranial Magnetic Stimulation</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Cortex moteur</term><term>Dystonie</term><term>Excitabilité</term><term>Homme</term><term>Pathologie du système nerveux</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="fr">A form of fixed dystonia (FD) without evidence of basal ganglia lesions or neurodegeneration has been recently characterized (Schrag et al., Brain 2004;127:2360‐2372), which may overlap the clinical spectrum of either complex regional pain syndrome or psychogenic dystonia. Transcranial magnetic stimulation studies in typically mobile dystonia revealed abnormal motor cortical excitability and sensori‐motor integration. We compared 12 patients with limb FD to 10 patients with primary adult‐onset typically mobile dystonia and 11 age‐matched healthy volunteers. Measurements at the first digital interosseus representation area on both hemispheres included: short intracortical inhibition (SICI), contralateral silent period (cSP), and short and long afferent inhibition (SAI and LAI). Repeated measure ANOVA and post‐hoc t‐tests were used for statistical analysis. SICI was significantly reduced in both hemispheres of patients with “typical” and FD, compared to healthy subjects. For both hemispheres, cSP duration was shorter in both fixed and “typical” dystonia patients. SAI and LAI did not significantly differ between the three groups. The abnormal cortical excitability observed in FD might represent an underlying trait predisposing to different clinical forms of dystonia. © 2007 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Gueldre</li></region><settlement><li>Londres</li><li>Nimègue</li></settlement></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Avanzino, Laura" sort="Avanzino, Laura" uniqKey="Avanzino L" first="Laura" last="Avanzino">Laura Avanzino</name></region><name sortKey="Bhatia, Kailash P" sort="Bhatia, Kailash P" uniqKey="Bhatia K" first="Kailash P." last="Bhatia">Kailash P. Bhatia</name><name sortKey="Martino, Davide" sort="Martino, Davide" uniqKey="Martino D" first="Davide" last="Martino">Davide Martino</name><name sortKey="Rothwell, John C" sort="Rothwell, John C" uniqKey="Rothwell J" first="John C." last="Rothwell">John C. Rothwell</name><name sortKey="Schneider, Susanne A" sort="Schneider, Susanne A" uniqKey="Schneider S" first="Susanne A." last="Schneider">Susanne A. Schneider</name><name sortKey="Schrag, Anette" sort="Schrag, Anette" uniqKey="Schrag A" first="Anette" last="Schrag">Anette Schrag</name><name sortKey="Van De Warrenburg, Bart P C" sort="Van De Warrenburg, Bart P C" uniqKey="Van De Warrenburg B" first="Bart P. C." last="Van De Warrenburg">Bart P. C. Van De Warrenburg</name></country><country name="Italie"><noRegion><name sortKey="Avanzino, Laura" sort="Avanzino, Laura" uniqKey="Avanzino L" first="Laura" last="Avanzino">Laura Avanzino</name></noRegion><name sortKey="Abbruzzese, Giovanni" sort="Abbruzzese, Giovanni" uniqKey="Abbruzzese G" first="Giovanni" last="Abbruzzese">Giovanni Abbruzzese</name><name sortKey="Defazio, Giovanni" sort="Defazio, Giovanni" uniqKey="Defazio G" first="Giovanni" last="Defazio">Giovanni Defazio</name><name sortKey="Martino, Davide" sort="Martino, Davide" uniqKey="Martino D" first="Davide" last="Martino">Davide Martino</name></country><country name="Pays-Bas"><region name="Gueldre"><name sortKey="Van De Warrenburg, Bart P C" sort="Van De Warrenburg, Bart P C" uniqKey="Van De Warrenburg B" first="Bart P. C." last="Van De Warrenburg">Bart P. C. Van De Warrenburg</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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